AP-6
AP-6 is a selective inhibitor of TMEM175 with activity in modulating lysosomal function. Acute inhibition of TMEM175 by AP-6 increases lysosomal macromolecular catabolism, thereby accelerating macrophage and other digestive processes. AP-6 may be used in Parkinson's disease research[1].
Product Specifications
CAS Number
1369963-51-8
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ap-6.html
Purity
99.84
Solubility
DMSO : 0.93 mg/mL (ultrasonic; warming; adjust pH to 3 with 1 M HCL; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=CC(C2=CC=CC(C3=CC(N)=CC=N3)=C2)=NC=C1
Molecular Formula
C16H14N4
Molecular Weight
262.31
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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