Amastatin

Amastatin is A slow, tightly bound, competitive inhibitor of aminopeptidase (AP) with an IC50 of 0.54 μg/mL for AP-A[1][2].

Product Specifications

CAS Number

[67655-94-1]

UNSPSC

12352211

Hazard Statement

H315-H319-H335

Target

Aminopeptidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/amastatin.html

Solubility

10 mM in DMSO

Smiles

O=C(C[C@H](NC([C@@H](NC([C@@H](NC([C@H]([C@@H](CC(C)C)N)O)=O)C(C)C)=O)C(C)C)=O)C(O)=O)O

Molecular Formula

C21H38N4O8

Molecular Weight

474.55

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Aoyagi T, et al. Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes. J Antibiot (Tokyo) . 1978 Jun;31 (6) :636-8.|[2]Wilkes SH, et al. The slow, tight binding of bestatin and amastatin to aminopeptidases. J Biol Chem. 1985 Oct 25;260 (24) :13154-62.