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Esomeprazole magnesium

Esomeprazole magnesium ((S) -Omeprazole magnesium) is a potent and orally active H+, K+-ATPase inhibitor. Esomeprazole magnesium has the potential for upper intestinal disorders and gastroesophageal reflux disease research[1][2]. Esomeprazole magnesium acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases[4].

Product Specifications

CAS Number

161973-10-0

Product Name Alternative

(S) -Omeprazole magnesium; (-) -Omeprazole magnesium

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Proton Pump

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/Esomeprazole_magnesium.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 3 mg/mL (ultrasonic)

Smiles

CC1=C(N=CC(C)=C1OC)CS2=O[Mg+2]3([N](C4=CC=C(OC)C=C4[N-]5)=C5S(CC(N=CC(C)=C6OC)=C6C)=O3)[N]7=C2[N-]C8=CC(OC)=CC=C78

Molecular Formula

C34H36MgN6O6S2

Molecular Weight

713.12

Precautions

H302, H315, H319, H335

References & Citations

[1]Timothy R Koch, et al. Effect of the H, K-ATPase inhibitor, esomeprazole magnesium, on gut total antioxidant capacity in mice. J Nutr Biochem. 2004 Sep;15 (9) :522-6.|[2]Pankaj Kumar, et al. Preparation and characterization of pH-sensitive methyl methacrylate-g-starch/hydroxypropylated starch hydrogels: in vitro and in vivo study on release of esomeprazole magnesium. Drug Deliv Transl Res. 2015 Jun;5 (3) :243-56.|[3]2013 Annual Meeting. Abstract Supplement|[4]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35 (1) :1322-1330.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Chem Eng J. 2024 Dec 1.|Int Immunopharmacol. 2025 Aug 13:164:115367.

Available Sizes

Frequently Asked Questions

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