ULK3 Recombinant Antibody, AbBy Fluor™ 647 Conjugated

Product Specifications

Background

Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3) . Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation.

Synonyms

Serine/threonine-protein kinase ULK3; Ulk3; unc 51 like kinase 3 (C. elegans) ; Unc-51-like kinase 3.

Gene ID

25989

Swiss Prot

Q6PHR2

Cellular Locus

Nucleus

Host

Rabbit

Cross Reactivity

Human

Target

ULK3

Clonality

Recombinant

Isotype

IgG

Conjugation

AbBy Fluor™ 647

Source

KLH conjugated synthetic peptide derived from human ULK3

Applications

WB, IF

Purification

Purified by Protein A.

Excitation Emission

650nm/665nm

Concentration

Lot dependent

Dilution

WB (1:300-5000), IF ()

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

25989

Available Sizes

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