16-Hydroxycleroda-3,13-dien-15,16-olide
16-Hydroxycleroda-3,13-dien-15,16-olide (16ξ-Hydroxycleroda-3,13-dien-15,16-olide; HCD), a clerodane diterpene, is a potent serine protease dipeptidyl peptidase 4 (DPP-4) inhibitor. 16-Hydroxycleroda-3,13-dien-15,16-olide down-regulates LPS-induced ERK phosphorylation in myocyte but blocks GLP-1 induced PKA expression. 16-Hydroxycleroda-3,13-dien-15,16-olide exhibits hypolipidemic, hepatoprotective, hypoglycemic efficacy[1].
Product Specifications
CAS Number
[141979-19-3]
Product Name Alternative
16ξ-Hydroxycleroda-3,13-dien-15,16-olide
UNSPSC
12352005
Target
Dipeptidyl Peptidase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/16-hydroxycleroda-3-13-dien-15-16-olide.html
Solubility
10 mM in DMSO
Smiles
OC(O1)C(CC[C@@]2([C@]3([H])[C@@](CC[C@H]2C)(C(C)=CCC3)C)C)=CC1=O
Molecular Formula
C20H30O3
Molecular Weight
318.45
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
DPP-4
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