LRRK2-IN-7
LRRK2-IN-7 is a potent, selective, and CNS-penetrant LRRK2 kinase inhibitor with an IC50 of 0.9 nM. LRRK2-IN-7 shows >1000-fold selectivity over other kinases, ion channels, and CYP enzymes[1].
Product Specifications
CAS Number
2307277-93-4
UNSPSC
12352005
Target
LRRK2
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lrrk2-in-7.html
Purity
98.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(O)[C@@H]1CCN(C1)C2=NC=NC(N3C4=CC([C@@]5(CC56CC6)C#N)=CC=C4C=N3)=C2
Molecular Formula
C24H26N6O
Molecular Weight
414.50
References & Citations
[1]David A Candito, et al. Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease. J Med Chem. 2022 Dec 22;65 (24) :16801-16817.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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