Cyclin H Recombinant Antibody, Cy3 Conjugated
Product Specifications
Background
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Synonyms
CAK; CAK complex subunit; CDK activating kinase; CDK activating kinase complex subunit; CyclinH; MO15 associated protein; p34; p36; p37.
Gene ID
902
Swiss Prot
P51946
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Cyclin H
Clonality
Recombinant
Isotype
IgG
Conjugation
Cy3
Source
KLH conjugated synthetic peptide derived from human Cyclin H
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
512,550nm/570,615nm
Concentration
Lot dependent
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
902
Available Sizes
Curated Selection
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