Olvanil

Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC50 of 0.7 nM[1].

Product Specifications

CAS Number

58493-49-5

Product Name Alternative

NE-19550; N-Vanillyloleamide

UNSPSC

12352005

Hazard Statement

H225, H319

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/olvanil.html

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCCCCCCC/C=C\CCCCCCCC(NCC1=CC=C(O)C(OC)=C1)=O

Molecular Formula

C26H43NO3

Molecular Weight

417.62

Precautions

H225, H319

References & Citations

[1]Giovanni Appendino, et al. Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential. J Pharmacol Exp Ther. 2005 Feb;312 (2) :561-70.|[2]S O Jacobsson, et al. Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors.J Pharmacol Exp Ther. 2001 Dec;299 (3) :951-9.|[3]John W Kasckow, et al. Effects of the vanilloid agonist olvanil and antagonist capsazepine on rat behaviors. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Mar;28 (2) :291-5.