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Phospho-CBL (Tyr774) Recombinant Antibody, FITC Conjugated

Product Specifications

Background

Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome.

Synonyms

Casitas B lineage lymphoma proto oncogene; CBL2; E3 ubiquitin protein ligase CBL; Oncogene CBL2; Proto oncogene c CBL; RING finger protein 55; RNF55; Signal transduction protein CBL.

Gene ID

867

Swiss Prot

P22681

Modification Site

Tyr774

Cellular Locus

Cytoplasm, Cell membrane

Host

Rabbit

Cross Reactivity

Human

Target

CBL (Tyr774)

Clonality

Recombinant

Isotype

IgG

Conjugation

FITC

Source

KLH conjugated synthetic peptide derived from human CBL around the phosphorylation site of Y774

Applications

WB, IF, Flow-Cyt

Purification

Purified Polyclonal A

Excitation Emission

494nm/518nm

Concentration

Lot dependent

Dilution

WB (1:300-5000), IF (), Flow-Cyt (1ug/Test)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

867

Available Sizes

Curated Selection

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