Phospho-beta Arrestin 1 (Ser412) Recombinant Antibody, PE Conjugated

Product Specifications

Background

Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation.

Synonyms

ARB1; ARR1; ARRB1; Arrestin 2; Arrestin beta 1.

Gene ID

408

Swiss Prot

P49407

Modification Site

Ser412

Cellular Locus

Cytoplasm, Nucleus, Cell membrane

Host

Rabbit

Cross Reactivity

Human

Target

Beta Arrestin 1

Clonality

Recombinant

Isotype

IgG

Conjugation

Source

KLH conjugated synthetic peptide derived from human beta Arrestin 1 around the phosphorylation site of S412

Applications

Purification

Purified by Protein A.

Excitation Emission

496,564nm/578nm

Concentration

Lot dependent

Dilution

WB (1:300-5000)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

408

Available Sizes

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