Gabapentin (hydrochloride)

Gabapentin hydrochloride is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin hydrochloride inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin hydrochloride is a GABA analog that can be used to relieve neuropathic pain[1][2][3].

Product Specifications

CAS Number

[60142-95-2]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Gabapentin-hydrochloride.html

Purity

98.0

Solubility

10 mM in DMSO|H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(O)CC1(CN)CCCCC1.[H]Cl

Molecular Formula

C9H18ClNO2

Molecular Weight

207.70

Precautions

H302, H315, H319, H335

References & Citations

[1]Fink K, et, al. Inhibition of neuronal Ca (2+) influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. Br J Pharmacol. 2000 Jun;130 (4) :900-6.|[2]Celikyurt IK, et, al. Gabapentin, A GABA analogue, enhances cognitive performance in mice. Neurosci Lett. 2011 Apr 1;492 (2) :124-8.|[3]Meymandi MS, et, al. Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice. Eur J Anaesthesiol. 2008 Feb;25 (2) :129-34.