LAMP1 Monoclonal Antibody
Product Specifications
Background
Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI) . Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
Synonyms
CD107 antigen like family member A; CD107 antigen-like family member A; CD107a; CD107a antigen; LAMP 1; LAMP-1; LAMP1_HUMAN; LAMPA; LGP120; lgpA; Lysosomal membrane glycoprotein 120KD; Lysosomal Associated Membrane Protein 1; Lysosome associated membrane glycoprotein 1; Lysosome-associated membrane glycoprotein 1; Lysosome-associated membrane glycoprotein 1; Lysosome-associated membrane protein 1; OTTHUMP00000040663.
Gene ID
3916
Swiss Prot
P11279
Cellular Locus
Cytoplasm, Cell membrane
Host
Mouse
Cross Reactivity
Human
Target
LAMP1
Clonality
Monoclonal
Isotype
IgG
Clone
A7D12
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human LAMP1
Applications
WB, ELISA
Purification
Purified by Protein A.
Concentration
1mg/ml
Dilution
WB (WB=1:500-1000), ELISA (ELISA=1:5000-10000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
3916
Curated Selection
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