PMP22 Monoclonal Antibody
Product Specifications
Background
PMP22 is a 22 kDa glycoprotein expressed in the compact myelin of the peripheral nervous system. In the peripheral nervous system, PMP 22 is produced by myelinating Schwann cells and is coexpressed with the genes for myelin basic protein (MBP) during nerve development and regeneration. Alterations in the level of this protein cause several genetic human diseases. If the protein is duplicated, patients develop Charcot Marie Tooth disease. If one copy of the gene is deleted, they suffer from the inherited tendency to pressure palsies.
Synonyms
GAS3; CMT1A; CMT1E; DSS; GAS-3; Growth Arrest Specific 3; Growth arrest-specific protein 3; HMSNIA; HNPP; MGC20769; Peripheral Myelin Protein 22; PMP-22; PMP22; PMP22_HUMAN; Sp110; Trembler.
Gene ID
5376
Swiss Prot
Q01453
Cellular Locus
Cell membrane
Host
Mouse
Cross Reactivity
Human
Target
PMP22
Clonality
Monoclonal
Isotype
IgG
Clone
2F7
Conjugation
Unconjugated
Source
Recombinant protein of human PMP22
Applications
IHC
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
IHC (1:100-500)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
5376
Predicted Cross Reactivity
Mouse, Rat
Curated Selection
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