Phospho-PLK1 (T210) Monoclonal Antibody
Product Specifications
Background
PLK1 (polo-like kinase 1) is a member of the serine/threonine protein kinase family, cdc5/polo subfamily. PLK1 contains two polo box domains with a predicted molecular weight of 68 kDa. PLK1 has been shown to regulate cdc2/cyclin B through phosphorylation and activation of cdc25c phosphatase. PLK1 is modified by phosphorylation at Threonine 210. PLK1 may also be required for cell division. Depletion of PLK1 results in apoptosis and deregulation of expression of PKL1 is correlated with development of many malignancies.
Synonyms
Cell cycle regulated protein kinase antibody, PLK 1 antibody, PLK antibody, PLK-1 antibody, plk1 antibody, PLK1_HUMAN antibody, Polo like kinase 1 antibody, Polo-like kinase 1 antibody, Serine/threonine protein kinase 13 antibody, Serine/threonine protein kinase PLK1 antibody, Serine/threonine-protein kinase 13 antibody, Serine/threonine-protein kinase PLK1 antibody, STPK 13 antibody, STPK13 antibody
Gene ID
5347
Swiss Prot
P53350
Modification Site
Thr210
Cellular Locus
Cytoplasm, Nucleus, Chromosome, Midbody
Host
Rabbit
Cross Reactivity
Human
Target
Phospho-PLK1 (T210)
Clonality
Monoclonal
Isotype
IgG
Clone
1H4
Conjugation
Unconjugated
Source
Synthetic phospho-Peptide corresponding to residues surrounding Thr210 of human PLK1.
Applications
WB, FCM, IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
5347
Curated Selection
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