Phospho-EGFR (Y1068) Monoclonal Antibody
Product Specifications
Background
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Synonyms
Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody, Cell growth inhibiting protein 40 antibody, Cell proliferation inducing protein 61 antibody, EGF R antibody, EGFR antibody, EGFR_HUMAN antibody, Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) antibody, Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian) antibody, Epidermal growth factor receptor antibody, erb-b2 receptor tyrosine kinase 1 antibody, ERBB antibody, ERBB1 antibody, Errp antibody, HER1 antibody, mENA antibody, NISBD2 antibody, Oncogen ERBB antibody, PIG61 antibody, Proto-oncogene c-ErbB-1 antibody, Receptor tyrosine protein kinase ErbB 1 antibody, Receptor tyrosine-protein kinase ErbB-1 antibody, SA7 antibody, Species antigen 7 antibody, Urogastrone antibody, v-erb-b Avian erythroblastic leukemia viral oncogen homolog antibody, wa2 antibody, Wa5 antibody
Gene ID
1956
Swiss Prot
P00533
Modification Site
Tyr1068
Cellular Locus
Nucleus, Secreted, Cell membrane, Endosome, Endoplasmic reticulum membrane, Golgi apparatus membrane, Nucleus membrane
Host
Rabbit
Cross Reactivity
Human
Target
Phospho-EGFR (Y1068)
Clonality
Monoclonal
Isotype
IgG
Clone
1H2
Conjugation
Unconjugated
Source
Synthetic phospho-Peptide corresponding to residues surrounding Tyr1068 of human EGFR.
Applications
WB, FCM, IF (ICC), IP
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IF (ICC) (1:50-200), IP (1-2ug)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
1956
Curated Selection
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