CD46 Recombinant Antibody, PE Conjugated
Product Specifications
Background
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Synonyms
Membrane cofactor protein; TLX; Trophoblast leukocyte common antigen; CD46; MCP; MIC10; AHUS2
Gene ID
4179
Swiss Prot
P15529
Host
Rabbit
Cross Reactivity
Human
Target
CD46
Clonality
Monoclonal
Isotype
IgG
Clone
4C3
Conjugation
PE
Source
Synthetic peptide within human CD46 aa 50-100
Applications
WB, IF
Purification
Purified by Protein A.
Excitation Emission
496,564nm/578nm
Concentration
Lot Dependent
Dilution
WB (1:300-5000), IF ()
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
4179
Curated Selection
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