ROS-generating agent 1

ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities[1].

Product Specifications

CAS Number

[2369030-41-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis; Ferroptosis; Reactive Oxygen Species (ROS) ; TrxR

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ros-generating-agent-1.html

Purity

99.11

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C1/C(CNC/C1=C\C2=CC(C(F)(F)F)=CC=C2)=C/C3=CC=CC(C(F)(F)F)=C3

Molecular Formula

C21H15F6NO

Molecular Weight

411.34

Precautions

H302, H315, H319

References & Citations

[1]Liu X, et al. Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition. Eur J Med Chem. 2023 Mar 15;250:115191.