Alpha Synuclein Recombinant Antibody, PE-Cy7 Conjugated
Product Specifications
Background
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity
Synonyms
Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; SNCA; NACP; PARK1; PARK4
Gene ID
6622
Swiss Prot
P37840
Cellular Locus
Cytoplasm, Nucleus, Secreted, Cell membrane
Host
Rabbit
Cross Reactivity
Human
Target
Alpha Synuclein
Clonality
Monoclonal
Isotype
IgG
Clone
3H12
Conjugation
PE-Cy7
Source
Recombinant full length Human protein
Applications
WB, Flow-Cyt
Purification
Purified by Protein A.
Excitation Emission
488nm/780nm
Concentration
Lot Dependent
Dilution
WB (1:300-5000), Flow-Cyt (1ug/Test)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
6622
Curated Selection
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