Alpha Synuclein Recombinant Antibody, Cy5 Conjugated
Product Specifications
Background
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity
Synonyms
Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; SNCA; NACP; PARK1; PARK4
Gene ID
6622
Swiss Prot
P37840
Cellular Locus
Cytoplasm, Nucleus, Secreted, Cell membrane
Host
Rabbit
Cross Reactivity
Human
Target
Alpha Synuclein
Clonality
Monoclonal
Isotype
IgG
Clone
3H12
Conjugation
Cy5
Source
Recombinant full length Human protein
Applications
WB, IF, Flow-Cyt
Purification
Purified by Protein A.
Excitation Emission
625,650nm/670nm
Concentration
Lot Dependent
Dilution
WB (1:300-5000), IF (), Flow-Cyt (1ug/Test)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
6622
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
