KAT2B (2C1) Monoclonal Antibody
Product Specifications
Background
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, PLK4 and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5. Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4. Also acetylates spermidine.
Synonyms
Histone acetyltransferase KAT2B; Histone acetyltransferase PCAF; Lysine acetyltransferase 2B; P300/CBP-associated factor; Histone acetylase PCAF; P/CAF; KAT2B; PCAF.
Gene ID
8850
Swiss Prot
Q92831
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
KAT2B
Clonality
Monoclonal
Isotype
IgG
Clone
2C1
Conjugation
Unconjugated
Source
Recombinant protein within human PCAF aa 100-300
Applications
WB, FCM, IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene ID URL
8850
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
NBP2-50389-0.025mL 0.025 mL
Mouse Monoclonal ERO1LB Antibody (M37-P5D11)
Sign In for Pricing
View Details 
302358-APC 200 µL
CLEC19A (C-Type lectin Domain Family 19 Member A, CLEC19A) (APC) discontinued
Sign In for Pricing
View Details