Staufen (8C8) Monoclonal Antibody
Product Specifications
Background
STAU1 (staufen, RNA binding protein, homolog 1) is a 577 amino acid protein that contains three double-stranded RNA-binding domains and is a mammalian homolog of Staufen, a Drosophila protein that is involved in mRNA transport during oogenesis and zygotic development. Localized to the rough endoplasmic reticulum (RER) and expressed in a variety of tissues, including heart, brain, liver, lung, pancreas, kidney and placenta, STAU1 binds to both Tubulin and double-stranded RNA and is thought to play an important role in mRNA transport from the microtubule network to the RER. Additionally, STAU1 may be involved in cross-linking cytoskeletal components with RNA, an event that is important for proper mRNA positioning during translation. Alternative splicing of the STAU1 gene yields two STAU1 isoforms, designated short and long.
Synonyms
Double-stranded RNA-binding protein Staufen homolog 1; PPP1R150; STAU1; STAU.
Gene ID
6780
Swiss Prot
O95793
Cellular Locus
Cytoplasm, Endoplasmic reticulum
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
STAU1
Clonality
Monoclonal
Isotype
IgG
Clone
8C8
Conjugation
Unconjugated
Source
Recombinant protein within human Staufen aa 400-550
Applications
WB, FCM, IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene ID URL
6780
Curated Selection
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