TMEM173 (1B8) Monoclonal Antibody

Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta) . Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) . Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.

Stimulator of interferon genes protein; Endoplasmic reticulum interferon stimulator; Mediator of IRF3 activation; Transmembrane protein 173; hSTING; ERIS; hMITA; TMEM173; ERIS; MITA; STING.