Phospho-MLKL (Ser345) Recombinant Antibody, APC-Cy5.5 Conjugated

Product Specifications

Background

Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

Synonyms

Phospho-MLKL (S345) ; pMLKL Ser345; Mixed lineage kinase domain-like protein, Mlkl

Gene ID

74568

Swiss Prot

Q9D2Y4

Modification Site

Ser345

Host

Rabbit

Cross Reactivity

Mouse

Target

Phospho-MLKL (Ser345)

Clonality

Recombinant

Isotype

IgG

Conjugation

APC-Cy5.5

Source

Synthetic phospho-peptide corresponding to residues surrounding Ser345 of human MLKL

Applications

Purification

Purified by Protein A.

Excitation Emission

650nm/694nm

Concentration

Lot dependent

Dilution

WB (1:300-5000)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

74568

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