H3K27me2/3 (11D1) Monoclonal Antibody
Product Specifications
Background
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Gene ID
8350
Swiss Prot
P68431
Host
Mouse
Cross Reactivity
Human
Target
H3K27me2/3
Clonality
Monoclonal
Clone
11D1
Conjugation
Unconjugated
Source
Monoclonal antibody raised in mouse against histone H3, di- or trimethylated at lysine 27 (H3K27me2/3), using a KLH-conjugated synthetic peptide.
Applications
WB, dot-blot
Purification
Protein G purified monoclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300
Concentration
1.5µg/µl
Dilution
WB (1:300-5000), dot-blot ()
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
8350
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