MMP13 Recombinant Antibody, Cy5 Conjugated
Product Specifications
Background
Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
Synonyms
Collagenase 3, Matrix metalloproteinase-13, MMP-13, MMP13
Gene ID
4322
Swiss Prot
P45452
Host
Rabbit
Cross Reactivity
Human
Target
MMP13
Clonality
Recombinant
Isotype
IgG
Conjugation
Cy5
Source
N terminus human MMP13
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
625,650nm/670nm
Concentration
Lot dependent
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
4322
Predicted Cross Reactivity
Mouse
Curated Selection
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