TFRC Recombinant Antibody, PE-Cy5.5 Conjugated
Product Specifications
Background
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Synonyms
Transferrin receptor protein 1, T9, p90, CD_antigen: CD71, TR, TfR, TfR1, Trfr, TFRC
Gene ID
P02786
Swiss Prot
P02786
Host
Rabbit
Cross Reactivity
Human, Rat
Target
TFRC
Clonality
Recombinant
Isotype
IgG
Conjugation
PE-Cy5.5
Source
Human Transferrin Receptor between 100 to 450 amino acids
Applications
WB, Flow-Cyt
Purification
Purified by Protein A.
Excitation Emission
488nm/694nm
Concentration
Lot dependent
Dilution
WB (1:300-5000), Flow-Cyt (1ug/Test)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
P02786
Predicted Cross Reactivity
Mouse
Curated Selection
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