Dnmt3b Recombinant Antibody
Product Specifications
Background
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity) . In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.
Synonyms
DNA (cytosine-5) -methyltransferase 3B, DNA methyltransferase HsaIIIB, Dnmt3b, DNA MTase HsaIIIB, M.HsaIIIB, DNMT3B
Gene ID
1789
Swiss Prot
Q9UBC3
Host
Rabbit
Target
Dnmt3b
Clonality
Recombinant
Isotype
IgG
Conjugation
Unconjugated
Source
Recombinant human protein DUSP6 between 350 to C-terminus
Applications
WB
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Product Datasheet
https://www.biossantibodies.com/datasheets/bsm-52355R
Gene ID URL
1789
Predicted Cross Reactivity
Human, Mouse, Rat
Available Sizes
Curated Selection
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