MLKL Recombinant Antibody, APC-Cy7 Conjugated
Product Specifications
Background
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671) . Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610) .
Synonyms
Mixed lineage kinase domain-like protein, hMLKL; MLKL
Gene ID
197259
Swiss Prot
Q8NB16
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human
Immunogen
350-471/471
Target
MLKL
Clonality
Recombinant
Isotype
IgG
Conjugation
APC-Cy7
Source
Human MLKL between 350 to C-terminus
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
650nm/780nm
Concentration
Lot dependent
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
197259
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