MLKL Recombinant Antibody, APC-Cy5.5 Conjugated

Product Specifications

Background

Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671) . Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610) .

Synonyms

Mixed lineage kinase domain-like protein, hMLKL; MLKL

Gene ID

197259

Swiss Prot

Q8NB16

Cellular Locus

Cell membrane

Host

Rabbit

Cross Reactivity

Human

Immunogen

350-471/471

Target

MLKL

Clonality

Recombinant

Isotype

IgG

Conjugation

APC-Cy5.5

Source

Human MLKL between 350 to C-terminus

Applications

Purification

Purified by Protein A.

Excitation Emission

650nm/694nm

Concentration

Lot dependent

Dilution

WB (1:300-5000)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

197259

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