FOXO3a (Ser253) Monoclonal Antibody, APC-Cy7 Conjugated

Product Specifications

Background

Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.

Synonyms

FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1; FOXO3

Gene ID

2309

Swiss Prot

O43524

Modification Site

S253

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Target

FOXO3a (Ser253)

Clonality

Monoclonal

Isotype

IgG

Clone

25B3

Conjugation

APC-Cy7

Source

Synthetic peptide derived from human FOXO3a (S253), around 230-280aa (phospho S253) .

Applications

Purification

Purified by Protein A.

Excitation Emission

650nm/780nm

Concentration

1µg/µl

Dilution

WB (1:300-5000)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

2309

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