FOXO3a (Ser253) Monoclonal Antibody, APC-Cy5.5 Conjugated
Product Specifications
Background
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Synonyms
FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1; FOXO3
Gene ID
2309
Swiss Prot
O43524
Modification Site
S253
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
FOXO3a (Ser253)
Clonality
Monoclonal
Isotype
IgG
Clone
25B3
Conjugation
APC-Cy5.5
Source
Synthetic peptide derived from human FOXO3a (S253), around 230-280aa (phospho S253) .
Applications
WB, IF
Purification
Purified by Protein A.
Excitation Emission
650nm/694nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF ()
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
2309
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