HDAC2 Monoclonal Antibody, PE Conjugated
Product Specifications
Background
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
Synonyms
HD2; RPD3; YAF1; Histone deacetylase 2; HDAC2
Gene ID
3066
Swiss Prot
Q92769
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
HDAC2
Clonality
Monoclonal
Isotype
IgG
Clone
3F9
Conjugation
PE
Source
Recombinant human HDAC2 protein, around N-terminal 100aa.
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
496,564nm/578nm
Concentration
Lot Dependent
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
3066
Curated Selection
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