Cyclin E1 Recombinant Antibody, Biotin Conjugated
Product Specifications
Background
Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
Synonyms
Cyclin E1 phospho T77; p-Cyclin E1 phospho T77; Cyclin E1 Thr77; CCNE 1; CCNE; CCNE1; Cyclin E1 antibody Cyclin Es; Cyclin Et; CyclinE; G1/S specic cyclin E.
Gene ID
898
Swiss Prot
P24864
Host
Rabbit
Cross Reactivity
Human
Target
Cyclin E1
Clonality
Recombinant
Isotype
IgG
Conjugation
Biotin
Source
Synthetic peptide derive from human cyclin e1
Applications
WB, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
Lot dependent
Dilution
WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
898
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