Cyclin E1 Recombinant Antibody, AbBy Fluor™ 405 Conjugated

Product Specifications

Background

Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.

Synonyms

Cyclin E1 phospho T77; p-Cyclin E1 phospho T77; Cyclin E1 Thr77; CCNE 1; CCNE; CCNE1; Cyclin E1 antibody Cyclin Es; Cyclin Et; CyclinE; G1/S specic cyclin E.

Gene ID

898

Swiss Prot

P24864

Host

Rabbit

Cross Reactivity

Human

Target

Cyclin E1

Clonality

Recombinant

Isotype

IgG

Conjugation

AbBy Fluor™ 405

Source

Synthetic peptide derive from human cyclin e1

Applications

WB, IF

Purification

Purified by Protein A.

Excitation Emission

401nm/421nm

Concentration

Lot dependent

Dilution

WB (1:300-5000), IF ()

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

898

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