RIPK3 Monoclonal Antibody
Product Specifications
Background
Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Synonyms
Receptor interacting protein 3; Receptor interacting serine threonine kinase 3; Receptor interacting serine/threonine protein kinase 3; Receptor-interacting protein 3; Receptor-interacting serine/threonine-protein kinase 3; RIP 3; RIP like protein kinase 3; RIP-3; RIP-like protein kinase 3; RIPK 3; RIPK3_HUMAN.
Gene ID
11035
Swiss Prot
Q9Y572
Cellular Locus
Cytoplasm, Cell membrane
Host
Mouse
Cross Reactivity
Human
Target
RIPK3
Clonality
Monoclonal
Clone
D11F6
Conjugation
Unconjugated
Source
Recombinant human RIPK3.
Applications
WB
Concentration
0.5µg/µl
Dilution
WB (WB=1:500-1000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
11035
Curated Selection
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