HIF1AN Monoclonal Antibody
Product Specifications
Background
Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminaltransactivation domain (CAD) . Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interactionof HIF-1 with transcriptional coactivators includingCbp/p300-interacting transactivator. Involved in transcriptionalrepression through interaction with HIF1A, VHL and histonedeacetylases. Hydroxylates specific Asn residues within ankyrinrepeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A andseveral other ARD-containing proteins. Also hydroxylates Asp andHis residues within ARDs of ANK1 and TNKS2, respectively.Negatively regulates NOTCH1 activity, accelerating myogenicdifferentiation. Positively regulates ASB4 activity, promotingvascular differentiation.
Synonyms
Hypoxia inducible factor asparagine hydroxylase; Factor inhibiting HIF1; FIH 1; FIH-1; FIH1; Hypoxia inducible factor 1 alpha inhibitor; Hypoxia inducible factor 1 alpha subunit inhibitor; Peptide aspartate beta dioxygenase; DKFZp762F1811; FLJ20615; FLJ22027; HIF1N_HUMAN.
Gene ID
55662
Swiss Prot
Q9NWT6
Cellular Locus
Nucleus
Host
Mouse
Cross Reactivity
Human
Immunogen
1-349/349
Target
HIF1AN
Clonality
Monoclonal
Clone
L8U9
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human HIF1AN
Applications
WB, ICC/IF
Concentration
0.5µg/µl
Dilution
WB (WB=1:500-2000), ICC/IF (ICC/IF=1:20-50)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
55662
Curated Selection
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