USP5 Monoclonal Antibody
Product Specifications
Background
Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Synonyms
Deubiquitinating enzyme 5; Isopeptidase T; ISOT 1; ISOT; Ubiquitin carboxyl-terminal hydrolase 5; Ubiquitin isopeptidase T; Ubiquitin specific peptidase 5 (isopeptidase T) ; Ubiquitin specific peptidase 5; Ubiquitin specific processing protease 5; Ubiquitin specific protease 5 (isopeptidase T) ; Ubiquitin specific protease 5 (ubiquitin isopeptidase T) ; Ubiquitin thioesterase 5; Ubiquitin thiolesterase 5; Ubiquitin-specific-processing protease 5; UBP5_HUMAN; USP-5; USP 5
Gene ID
8078
Swiss Prot
P45974
Cellular Locus
Cytoplasm, Nucleus
Host
Mouse
Cross Reactivity
Human, Mouse, Rat
Target
USP5
Clonality
Monoclonal
Isotype
IgG1
Clone
H4Y13
Conjugation
Unconjugated
Source
Recombinant human USP5.
Applications
WB
Purification
Purified by Protein G.
Concentration
0.5µg/µl
Dilution
WB (WB (1:500-2000) )
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
8078
Curated Selection
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