MAGED1 Monoclonal Antibody
Product Specifications
Background
Involved in the apoptotic response after nerve growthfactor (NGF) binding in neuronal cells. Binds NGFR/p75NTR andantagonizes its association with NTRK1/TrkA, inhibits cell cycleprogression, and facilitates NGFR-mediated apoptosis. May act as aregulator of the function of DLX family members. May regulateTP53/p53 transcriptional activity and inhibit cell proliferation.Enhances TP53 phosphorylation and accumulation. May enhanceubiquitin ligase activity of RING-type zinc finger-containing E3ubiquitin-protein ligases. Proposed to act through recruitmentand/or stabilization of the Ubl-conjugating enzyme (E2) at theE3:substrate complex.
Synonyms
DLXIN 1; MAGD1_HUMAN; MAGE D1 antigen; MAGE tumor antigen CCF; MAGE-D1 antigen; Melanoma antigen family D 1; Melanoma associated antigen D1; Melanoma-associated antigen D1; Neurotrophin receptor interacting MAGE homolog; Neurotrophin receptor-interacting MAGE homolog; NRAGE; PP2250.
Gene ID
9500
Swiss Prot
Q9Y5V3
Cellular Locus
Cytoplasm, Nucleus, Cell membrane
Host
Mouse
Cross Reactivity
Human
Immunogen
50-200/778
Target
MAGED1
Clonality
Monoclonal
Clone
C5D3
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human MAGED1
Applications
WB
Concentration
0.5µg/µl
Dilution
WB (WB=1:500-1000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
9500
Curated Selection
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