RAB23 Monoclonal Antibody
Product Specifications
Background
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.
Synonyms
DKFZp781H0695; HSPC137; MGC8900; Rab 23; RAB family small GTP binding protein RAB 23; RAB23, member RAS oncogene family; RAB23_HUMAN; Ras related protein Rab 23; Ras-related protein Rab-23.
Gene ID
51715
Swiss Prot
Q9ULC3
Cellular Locus
Cytoplasm, Cell membrane
Host
Mouse
Cross Reactivity
Human, Mouse
Target
RAB23
Clonality
Monoclonal
Isotype
IgG1
Clone
G6S4
Conjugation
Unconjugated
Source
Recombinant human RAB23 (Fragment) (His-tagged) .
Applications
WB, ELISA, Flow-Cyt
Concentration
0.5µg/µl
Dilution
WB (WB=1:500-2000), ELISA (ELISA=1:5000-10000), Flow-Cyt (Flow-Cyt=1:25)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Product Datasheet
https://www.biossantibodies.com/datasheets/bsm-51516M
Gene ID URL
51715
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