PIN1 Monoclonal Antibody
Product Specifications
Background
Essential PPIase that regulates mitosis presumably byinteracting with NIMA and attenuating its mitosis-promotingactivity. Displays a preference for an acidic residue N-terminal tothe isomerized proline bond. Catalyzes pSer/Thr-Pro cis/transisomerizations. Down-regulates kinase activity of BTK. Cantransactivate multiple oncogenes and induce centrosomeamplification, chromosome instability and cell transformation.Required for the efficient dephosphorylation and recycling of RAF1after mitogen activation.
Synonyms
DOD; NIMA interacting 1; Peptidyl prolyl cis trans isomerase NIMA interacting 1; Peptidyl prolyl cis/trans isomerase NIMA interacting; Pin 1; PPIase Pin1; Prolyl isomerase; Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1; Protein NIMA interacting 1; Rotamase Pin1; UBL 5; UBL5; PIN1_HUMAN.
Gene ID
5300
Swiss Prot
Q13526
Cellular Locus
Cytoplasm, Nucleus
Host
Mouse
Cross Reactivity
Mouse
Target
PIN1
Clonality
Monoclonal
Isotype
IgG1
Clone
F12S3
Conjugation
Unconjugated
Source
Recombinant human UBL5 (Fragment) (His-tagged) .
Applications
WB
Concentration
0.5µg/µl
Dilution
WB (WB=1:500-2000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
5300
Predicted Cross Reactivity
Human, Cow
Curated Selection
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