PIN1 Monoclonal Antibody

Product Specifications

Background

Essential PPIase that regulates mitosis presumably byinteracting with NIMA and attenuating its mitosis-promotingactivity. Displays a preference for an acidic residue N-terminal tothe isomerized proline bond. Catalyzes pSer/Thr-Pro cis/transisomerizations. Down-regulates kinase activity of BTK. Cantransactivate multiple oncogenes and induce centrosomeamplification, chromosome instability and cell transformation.Required for the efficient dephosphorylation and recycling of RAF1after mitogen activation.

Synonyms

DOD; NIMA interacting 1; Peptidyl prolyl cis trans isomerase NIMA interacting 1; Peptidyl prolyl cis/trans isomerase NIMA interacting; Pin 1; PPIase Pin1; Prolyl isomerase; Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1; Protein NIMA interacting 1; Rotamase Pin1; UBL 5; UBL5; PIN1_HUMAN.

Gene ID

5300

Swiss Prot

Q13526

Cellular Locus

Cytoplasm, Nucleus

Host

Mouse

Cross Reactivity

Mouse

Target

PIN1

Clonality

Monoclonal

Isotype

IgG1

Clone

F12S3

Conjugation

Unconjugated

Source

Recombinant human UBL5 (Fragment) (His-tagged) .

Applications

Concentration

0.5µg/µl

Dilution

WB (WB=1:500-2000)

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Gene ID URL

5300

Predicted Cross Reactivity

Human, Cow

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