TSC1 Monoclonal Antibody
Product Specifications
Background
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
Synonyms
LAM; Hamartin; Tuberous sclerosis 1 protein; TSC1_HUMAN; KIAA0243; TSC; Tuberous sclerosis 1.
Gene ID
7248
Swiss Prot
Q92574
Cellular Locus
Cytoplasm, Cell membrane
Host
Mouse
Cross Reactivity
Mouse
Target
TSC1
Clonality
Monoclonal
Isotype
IgG2b
Clone
K6F13
Conjugation
Unconjugated
Source
Recombinant human TSC1 (Fragment) (His-tagged) .
Applications
WB
Concentration
0.5µg/µl
Dilution
WB (WB=1:500-2000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
7248
Predicted Cross Reactivity
Human
Curated Selection
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