VRK1 (5C1) Monoclonal Antibody
Product Specifications
Background
Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.
Synonyms
PCH1; PCH1A; Serine/threonine-protein kinase VRK1; Vaccinia-related kinase 1; VRK1
Gene ID
7443
Swiss Prot
Q99986
Host
Mouse
Cross Reactivity
Human
Target
VRK1
Clonality
Monoclonal
Isotype
IgG1
Clone
5C1
Conjugation
Unconjugated
Source
Purified His-tagged VRK1 protein was used to produced this monoclonal antibody.
Applications
WB
Purification
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
Concentration
0.5µg/µl
Dilution
WB (1:300-5000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
7443
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
