MBD3 (5C3) Monoclonal Antibody
Product Specifications
Background
Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384) . Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro) . Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175) . Recruits histone deacetylases and DNA methyltransferases.
Synonyms
Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3; MBD3
Gene ID
53615
Swiss Prot
O95983
Host
Mouse
Cross Reactivity
Human
Target
MBD3
Clonality
Monoclonal
Isotype
IgG1
Clone
5C3
Conjugation
Unconjugated
Source
Purified His-tagged MBD3 protein was used to produced this monoclonal antibody.
Applications
WB
Purification
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Concentration
0.5µg/µl
Dilution
WB (1:300-5000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
53615
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