TFRC (4C1) Monoclonal Antibody
Product Specifications
Background
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
Synonyms
T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46; Transferrin receptor protein 1; TFRC
Gene ID
7037
Swiss Prot
P02786
Host
Mouse
Cross Reactivity
Human
Target
TFRC
Clonality
Monoclonal
Isotype
IgM
Clone
4C1
Conjugation
Unconjugated
Source
This TFRC antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 649-677 amino acids from human TFRC.
Applications
WB
Purification
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
Concentration
0.5µg/µl
Dilution
WB (1:300-5000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
7037
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