SU1261

SU1261 is an IKK inhibitor with Ki values of 10 nM and 680 nM for IKKα and IKKβ, respectively. SU1261 can inhibit non-canonical NF-κB signaling in U2OS osteosarcoma cells[1].

Product Specifications

CAS Number

[3061890-98-7]

UNSPSC

12352005

Target

IKK; NF-κB

Type

Reference compound

Related Pathways

NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/su1261.html

Purity

99.13

Solubility

DMSO : ≥ 100 mg/mL

Smiles

NC1=NNC(C=C2)=C1C=C2C(C=CN=C3N4)=C3C=C4C5=CC=CC(OCC6=CC=CC=C6)=C5

Molecular Formula

C27H21N5O

Molecular Weight

431.49

References & Citations

[1]Riley C, et al. Design and Synthesis of Novel Aminoindazole-pyrrolo[2,3-b]pyridine Inhibitors of IKKα That Selectively Perturb Cellular Non-Canonical NF-κB Signalling. Molecules. 2024 Jul 26;29 (15) :3515.