BI-1347
BI-1347 is an orally active, selective and potent CDK8 inhibitor (IC50=1.1 nM) . BI-1347 shows anti-tumoral activity[1][2].
Product Specifications
CAS Number
2163056-91-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bi-1347.html
Purity
99.84
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N(C)C)CN1N=CC(C2=CC=C(C3=CN=CC4=C3C=CC=C4)C=C2)=C1
Molecular Formula
C22H20N4O
Molecular Weight
356.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Harald Engelhardt, et al. New phenylpyrazolylacetamide compounds and derivatives as cdk8/cdk19 inhibitors.|[2]Hofmann MH, et al. Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol Cancer Ther. 2020 Apr;19 (4) :1018-1030.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK8
Available Sizes
Frequently Asked Questions
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