Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

BI-1347

BI-1347 is an orally active, selective and potent CDK8 inhibitor (IC50=1.1 nM) . BI-1347 shows anti-tumoral activity[1][2].

Product Specifications

CAS Number

2163056-91-3

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bi-1347.html

Purity

99.84

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(N(C)C)CN1N=CC(C2=CC=C(C3=CN=CC4=C3C=CC=C4)C=C2)=C1

Molecular Formula

C22H20N4O

Molecular Weight

356.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Harald Engelhardt, et al. New phenylpyrazolylacetamide compounds and derivatives as cdk8/cdk19 inhibitors.|[2]Hofmann MH, et al. Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol Cancer Ther. 2020 Apr;19 (4) :1018-1030.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK8

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Cog5 Mouse Gene Knockout Kit (CRISPR)
KN503608 1 Kit

Cog5 Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
hCG beta (CGB3) Mouse Monoclonal Antibody [Clone ID: HCG-8]
AM20627PU-N 100 µg

hCG beta (CGB3) Mouse Monoclonal Antibody [Clone ID: HCG-8]

Sign In for Pricing
View Details
4-Bromophenol-1,2,3,4,5,6-13C6
TRC-B686406-50MG 50 mg

4-Bromophenol-1,2,3,4,5,6-13C6

Sign In for Pricing
View Details
p21 (CDKN1A) Rabbit Monoclonal Antibody
TA422238 100 µL

p21 (CDKN1A) Rabbit Monoclonal Antibody

Sign In for Pricing
View Details
Recombinant Mouse IL-7 Rα/CD127 Protein (Fc Tag)
PDMM100157-01 20 µg

Recombinant Mouse IL-7 Rα/CD127 Protein (Fc Tag)

Sign In for Pricing
View Details
Recombinant Mouse IL-7 Rα/CD127 Protein (Fc Tag)
PDMM100157-02 100 µg

Recombinant Mouse IL-7 Rα/CD127 Protein (Fc Tag)

Sign In for Pricing
View Details