NKX2-1 Monoclonal Antibody
Product Specifications
Background
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Apr 2011]
Synonyms
NKX21_HUMAN; Homeobox protein Nkx-2.1; Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1 (TTF-1) ; Thyroid-specific enhancer-binding protein (T/EBP) ; NKX2A; TITF1; TTF1; TTF-1; NK2 homeobox 1; BCH; BHC; NK-2; TEBP; NMTC1; T/EBP
Gene ID
7080
Swiss Prot
P43699
Cellular Locus
Nucleus
Host
Mouse
Cross Reactivity
Human
Target
NKX2-1
Clonality
Monoclonal
Isotype
IgG
Conjugation
Unconjugated
Source
Recombinant human NKX2-1 protein
Applications
IHC
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
IHC ()
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
7080
Predicted Cross Reactivity
Mouse, Rat
Curated Selection
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