NBD-556
NBD-556, a CD4 mimetic, is a potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction. NBD-556 shows potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels[1][2].
Product Specifications
CAS Number
333353-44-9
UNSPSC
12352005
Hazard Statement
H301
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nbd-556.html
Purity
99.57
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(C(NC1CC(C)(NC(C)(C1)C)C)=O)NC2=CC=C(C=C2)Cl
Molecular Formula
C17H24ClN3O2
Molecular Weight
337.84
Precautions
H301
References & Citations
[1]Schon A, et al. Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120. Biochemistry. 2006 Sep 12;45 (36) :10973-10980.|[2]Zhao Q, Ma L, Jiang S, Lu H, Liu S, He Y, Strick N, Neamati N, Debnath AK.
 Identification of N-phenyl-N'- (2,2,6,6-tetramethyl-piperidin-4-yl) -oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4.
 Virology. 2005 Sep 1;339 (2) :213-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
Available Sizes
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